Ingredient profile
Niacin and Vitamin E Supplement Facts in Protoflow: 75 mg and 13 mg
The niacin and vitamin E supplement lines in Protoflow are niacin 75 mg (469% DV) and vitamin E 13 mg (87% DV) per 2 capsules. The niacin is more than twice the 35 mg adult upper limit for supplements and can cause flushing. The vitamin E is far below the 400 IU dose tied to prostate cancer risk in the SELECT trial.
Written by the Protoflow label deskUpdated
Niacin
Is 75 mg of niacin above the upper limit?
Yes. The adult upper limit for niacin from supplements is 35 mg a day, and two capsules hold 75 mg.
The label shows "Niacin (Vitamin B3)" at 75 mg per serving, which is 469% of the 16 mg Daily Value. The 35 mg upper limit is a ceiling for adults 19 and older who are not under medical care, not a goal (NIH ODS, Niacin). Protoflow is 2.1 times that ceiling.
The label does not say if the form is nicotinic acid or niacinamide. Nicotinic acid is the form that flushes.
Many "T booster" products also run high on niacin. A review of 50 of them found a median of 187.5% of the RDA for vitamin B3 (Clemesha et al., World J Mens Health 2020). Protoflow is above that, so do not stack it with a B-complex, a multivitamin with niacin or an energy drink.
Flush and liver
What is the niacin flush, and is 75 mg a risk for the liver?
The flush is warm, red, itchy skin. It is unpleasant, not toxic, and 75 mg is far from the doses linked to liver harm.
Flushing typically starts at about 30 to 50 mg of nicotinic acid. It shows up on the face, arms and chest as burning, tingling or itching (NIH ODS, Niacin). At 75 mg, some people will feel it and some will not.
Liver harm is tied to pharmacologic doses of 1,000 to 3,000 mg a day taken for months or years (NIH ODS, Niacin). That is about 13 to 40 times the Protoflow amount. The risk is higher with extended-release forms.
We do not call 75 mg dangerous, and we do not call it safe for everyone. It is above the limit, so people with liver disease, gout, diabetes or stomach ulcers should ask a doctor first.
| Amount | What it means |
|---|---|
| 16 mg | Adult Daily Value |
| 35 mg | Upper limit from supplements |
| 30 to 50 mg | Flushing is common |
| 75 mg | Protoflow, per 2 capsules |
| 1,000 to 3,000 mg | Doses linked to liver injury |
Why it is there
Why is niacin in a prostate formula?
The label gives no reason. Niacin is a vitamin, and no study ties it to the prostate.
Niacin helps the body turn food into energy. It is not a prostate nutrient. The sales page does not name niacin or vitamin E at all (Protoflow sales page), and the front of the bottle makes no niacin claim.
Our read: it is a vitamin added to a herb formula. Whatever the reason, the amount counts toward your daily total.
Can niacin interact with statins? It can: high-dose niacin is used with statins under a doctor's care, and the combination is watched. We read no interaction study for 75 mg, so ask your prescriber. Keep taking what you were prescribed.
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See packsVitamin E
Does vitamin E raise prostate cancer risk?
At 400 IU a day it did in one large trial. Protoflow has about 19 IU, far less.
Protoflow lists vitamin E as D-alpha tocopheryl succinate at 13 mg, or 87% DV. The natural form converts at 1 mg to 1.49 IU, so 13 mg is about 19 IU. The upper limit is 1,000 mg (NIH ODS, Vitamin E).
In SELECT, nearly 35,000 men took 400 IU of synthetic vitamin E, or placebo. Prostate cancer occurred in 620 men on vitamin E and 529 on placebo, a hazard ratio of 1.17 (Klein et al., JAMA 2011 (SELECT)). That is about 1.6 extra cases per 1,000 person-years.
The trial dose was 400 IU, about 180 mg. Protoflow is under a tenth of that, and SELECT did not test small doses. Large vitamin E doses may add bleeding risk with warfarin (NIH ODS, Vitamin E); Protoflow also has ginkgo, so tell your doctor if you take a blood thinner.
Label profile
What does the label print for these two lines?
Two lines, two amounts, one Daily Value each.
The panels below follow the Supplement Facts as printed. Next steps for the other ingredients follow the cards.
| Name on the label | Vitamin E (as D-Alpha Tocopheryl Succinate) |
|---|---|
| What it is | Natural-source vitamin E (d-alpha), succinate form |
| Group on this site | Vitamins |
| Amount per 2 capsules | 13 mg per 2 capsules (87% DV) |
| Amount per capsule | about 6.5 mg |
| On the sales page's list of 8? | No: on the label only |
| Amount used in research | 15 mg a day meets adult needs; upper limit 1,000 mg |
| Strength of evidence | Helps only if you are low |
| Marketed or traditional use | Antioxidant vitamin |
| Main caution | 13 mg is about 19 IU, far below the 400 IU a day that raised prostate cancer risk in the SELECT trial. Do not stack vitamin E products. |
| Name on the label | Niacin (Vitamin B3) |
|---|---|
| What it is | Vitamin B3; the label does not say which form |
| Group on this site | Vitamins |
| Amount per 2 capsules | 75 mg per 2 capsules (469% DV) |
| Amount per capsule | about 37.5 mg |
| On the sales page's list of 8? | No: on the label only |
| Amount used in research | 16 mg a day is the Daily Value; upper limit 35 mg from supplements |
| Strength of evidence | Above the adult upper limit for supplements |
| Marketed or traditional use | Energy metabolism vitamin |
| Main caution | 75 mg is more than twice the 35 mg upper limit. Flushing (red, warm, itchy skin) is common from about 30-50 mg. Do not stack niacin products. |
FAQ
Niacin and vitamin E questions
01Is 75 mg of niacin above the upper limit?
Yes. The adult upper limit for niacin from supplements is 35 mg a day, and two Protoflow capsules hold 75 mg, or 469% DV (NIH ODS, Niacin). That is more than twice the limit. The limit does not apply to people taking niacin under medical supervision.
02What is the niacin flush?
It is a brief reddening, warmth, tingling or itching of the face, arms and chest, common from about 30 to 50 mg of nicotinic acid (NIH ODS, Niacin). It is unpleasant but not toxic. Taking the capsules with a meal may ease it.
03Is niacin 75 mg a risk for the liver?
Not at this amount, going by the evidence we read. Liver injury is linked to doses of 1,000 to 3,000 mg a day taken for months or years (NIH ODS, Niacin). People with liver disease should still ask a doctor, since 75 mg is above the limit.
04Why is niacin in a prostate formula?
The label does not say, and we found no study linking niacin to prostate health. It is a vitamin, and the sales page does not name it (Protoflow sales page). Treat it as an added vitamin that counts toward your daily total.
05Does vitamin E raise prostate cancer risk?
At 400 IU a day of synthetic vitamin E it did in the SELECT trial, with a hazard ratio of 1.17 (Klein et al., JAMA 2011 (SELECT)). Protoflow has 13 mg, about 19 IU, which is far lower. The trial did not test small doses.
06How many IU is 13 mg of vitamin E?
About 19 IU if it is the natural form, which converts at 1 mg to 1.49 IU, or about 29 IU if synthetic, at 2.22 IU per mg (NIH ODS, Vitamin E). The label lists D-alpha tocopheryl succinate, which is the natural d-alpha form.
07Can niacin interact with statins?
It can. Doctors sometimes combine high-dose niacin with a statin and monitor the person closely. We found no interaction study at 75 mg, so ask your prescriber and keep taking your statin as directed.
Who wrote this
Written and reviewed by
Pages built from the Protoflow label, the sales page and linked NIH, FDA, FTC, NHS and peer-reviewed sources.
Last updated . Learn about our editorial standards and how we check reviews. This website is run by Goprotoflow, a licensed U.S. retail desk for Protoflow, not by the manufacturer or by PhytoThrive Labs. We earn money when you buy through our order links.
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